Toward a science of metabolic engineering.

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Abstract

Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates. Recruitment of heterologous proteins enables extension of existing pathways to obtain new chemical products, alter posttranslational protein processing, and degrade recalcitrant wastes. Although some of the experimental and mathematical tools required for rational metabolic engineering are available, complex cellular responses to genetic perturbations can complicate predictive design.

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Journal

Journal ID (iso-abbrev): Science

Title: Science (New York, N.Y.)

Publisher: American Association for the Advancement of Science (AAAS)

ISSN: 0036-8075

ISSN (Print): 0036-8075

Publication date (Electronic): Jun 21 1991

Volume: 252

Issue: 5013

Affiliations

[1 ] California Institute of Technology, Pasadena 91125.

Article

DOI: 10.1126/science.2047876

PubMed ID: 2047876

SO-VID: 531a6edc-10c4-4a09-b36e-2ed445cb84b2

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