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Abstract

RNAs are underexploited targets for small molecule drugs or chemical probes of function. This may be due, in part, to a fundamental lack of understanding of the types of small molecules that bind RNA specifically and the types of RNA motifs that specifically bind small molecules. In this review, we describe recent advances in the development and design of small molecules that bind to RNA and modulate function that aim to fill this void.

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PubMed ID:: 22185671

DOI:: 10.1021/cb200447r

ScienceOpen disciplines: Chemistry

Keywords: Aminoglycosides,chemistry,metabolism,pharmacology,Anti-Bacterial Agents,Antiviral Agents,Bacteria,drug effects,growth & development,Bacterial Infections,drug therapy,microbiology,Binding Sites,Drug Design,Humans,Inverted Repeat Sequences,Molecular Sequence Data,Nucleotide Motifs,genetics,Protein Biosynthesis,RNA Viruses,RNA, Bacterial,antagonists & inhibitors,RNA, Ribosomal, 16S,RNA, Viral,Ribosome Subunits,Riboswitch,Small Molecule Libraries,Virus Diseases,virology

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ScienceOpen disciplines: Chemistry

Keywords: Aminoglycosides, chemistry, metabolism, pharmacology, Anti-Bacterial Agents, Antiviral Agents, Bacteria, drug effects, growth & development, Bacterial Infections, drug therapy, microbiology, Binding Sites, Drug Design, Humans, Inverted Repeat Sequences, Molecular Sequence Data, Nucleotide Motifs, genetics, Protein Biosynthesis, RNA Viruses, RNA, Bacterial, antagonists & inhibitors, RNA, Ribosomal, 16S, RNA, Viral, Ribosome Subunits, Riboswitch, Small Molecule Libraries, Virus Diseases, virology

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