Cell death: critical control points.

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Abstract

Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.

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Journal

Journal ID (iso-abbrev): Cell

Title: Cell

Publisher: Elsevier BV

ISSN: 0092-8674

ISSN (Print): 0092-8674

Publication date (Electronic): Jan 23 2004

Volume: 116

Issue: 2

Affiliations

[1 ] Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Article

Publisher Item ID: S0092867404000467

DOI: 10.1016/s0092-8674(04)00046-7

PubMed ID: 14744432

SO-VID: 33512abe-7d5e-4558-8d7d-bd20effee074

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