CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.

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Abstract

The efficacy of tamoxifen therapy for the treatment of breast cancer varies widely among individuals. Plasma concentrations of the active tamoxifen metabolite endoxifen are associated with the cytochrome P450 (CYP) 2D6 genotype. We examined the effects of concomitant use of selective serotonin reuptake inhibitor antidepressants, which are CYP2D6 enzyme inhibitors commonly prescribed to treat hot flashes in women who take tamoxifen, and genotypes for genes that encode tamoxifen-metabolizing enzymes on plasma concentrations of tamoxifen and its metabolites.

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Journal

Journal ID (iso-abbrev): J Natl Cancer Inst

Title: Journal of the National Cancer Institute

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2105

ISSN (Print): 0027-8874

Publication date (Electronic): Jan 05 2005

Volume: 97

Issue: 1

Affiliations

[1 ] Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Article

Publisher Item ID: 97/1/30

DOI: 10.1093/jnci/dji005

PubMed ID: 15632378

SO-VID: 31f2baeb-d34a-4af1-a459-a399af719d30

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