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Lebrikizumab treatment in adults with asthma.
Jonathan Corren
1 ,
Robert F Lemanske ,
Nicola A Hanania ,
Phillip E Korenblat ,
Merdad V Parsey ,
Joseph R Arron ,
Jeffrey M Harris ,
Heleen Scheerens ,
Lawren C Wu ,
Zheng Su ,
Sofia Mosesova ,
Mark D Eisner ,
Sean P Bohen ,
John G Matthews
Sep 22 2011
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Abstract
Many patients with asthma have uncontrolled disease despite treatment with inhaled glucocorticoids. One potential cause of the variability in response to treatment is heterogeneity in the role of interleukin-13 expression in the clinical asthma phenotype. We hypothesized that anti-interleukin-13 therapy would benefit patients with asthma who had a pretreatment profile consistent with interleukin-13 activity.