Rab proteins as membrane organizers.

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Abstract

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport. Rab proteins and their effectors coordinate consecutive stages of transport, such as vesicle formation, vesicle and organelle motility, and tethering of vesicles to their target compartment. These molecules are highly compartmentalized in organelle membranes, making them excellent candidates for determining transport specificity and organelle identity.

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Journal

Journal ID (iso-abbrev): Nat Rev Mol Cell Biol

Title: Nature reviews. Molecular cell biology

Publisher: Springer Science and Business Media LLC

ISSN: 1471-0072

ISSN (Print): 1471-0072

Publication date (Electronic): Feb 2001

Volume: 2

Issue: 2

Affiliations

[1 ] Max-Planck-Institute of Molecular Cell Biology and Genetics, c/o EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Zerial@EMBL-Heidelberg.de

Article

DOI: 10.1038/35052055

PubMed ID: 11252952

SO-VID: 115b853d-f55b-45a8-8f29-e52146c59494

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